ANTICANCER EFFECT OF THE ANTIRHEUMATIC DRUG LEFLUNOMIDE ON ORAL SQUAMOUS CELL CARCINOMA BY THE INHIBITION OF TUMOR ANGIOGENESIS

Anticancer effect of the antirheumatic drug leflunomide on oral squamous cell carcinoma by the inhibition of tumor angiogenesis

Abstract Objectives Leflunomide (LEF) is a conventional synthetic disease-modifying antirheumatic drug and suppresses T-cell proliferation and activity by inhibiting pyrimidine synthesis using dihydroorotase dehydrogenase (DHODH); however, several studies have demonstrated that LEF possesses anticancer and antiangiogenic effects in some malignant t

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A randomised trial comparing preoperative administration of single-dose kefazolin to kefazolin plus metronidazole as prophylactic antibiotics at caesarean section

Background.Caesarean section is a life-saving procedure which is associated with high rates of maternal and neonatal complications.It has been estimated that globally, 29.7 million births occur by caesarean section annually.The risk of postpartum infection is estimated to be five to ten times higher compared with normal vaginal delivery.Pregnancy-r

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